Abstract
The nortropane cocaine analogue, 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane (ZIENT), is a high affinity, selective serotonin transporter (SERT) ligand that has shown promise as a SERT imaging agent for single photon computed tomography (SPECT) when labeled with I-123. Synthesis of the labeling precursor, radiosynthesis of [(11)C]ZIENT, and in vivo evaluation in anesthetized and awake monkeys have been performed to determine the suitability of [(11)C]ZIENT as a PET agent for SERT imaging.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Brain / diagnostic imaging
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Brain / metabolism
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Carbon Radioisotopes
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Isotope Labeling
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Macaca fascicularis
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Macaca mulatta
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Male
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Nortropanes / chemical synthesis*
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Nortropanes / chemistry
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Nortropanes / pharmacokinetics
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Positron-Emission Tomography
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / chemistry
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Radiopharmaceuticals / pharmacokinetics
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Serotonin Plasma Membrane Transport Proteins / metabolism*
Substances
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2-carbomethoxy-3-(4'-(2-iodoethenyl)phenyl)nortropane
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Carbon Radioisotopes
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Nortropanes
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Radiopharmaceuticals
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Serotonin Plasma Membrane Transport Proteins